Concise synthesis of (+)-fastigiatine.

Concise synthesis of (+)-fastigiatine† †This manuscript is dedicated to Professor Gilbert Stork. ‡ ‡Electronic supplementary information (ESI) available: Experimental procedures and characterization data for all compounds are included. See DOI: 10.1039/c5sc03262h Click here for additional data file.

Pharmacological properties of some 3-substituted indole derivatives, a concise overview

Indole is a nitrogen-containing heterocycle. It is a very important motif in agriculture and pharmacy. Many compounds containing indole moiety has been isolated form nature. It is also an important part in natural alkaloids. Tryptophan is an amino acid which posses indole. 3-Sustituted indoles are the main group of its derivatives. Because the wide-spread application of 3-substituted indolic co...

New Strategy for the Synthesis of Morpholine Cores: Synthesis from N-Propargylamines

Functionalized morpholines have attracted much attention due to their potential biological activities. Despite the wide importance of morpholine derivatives in drug design of various pharmacological agents, the development of new approaches to their synthesis remains relatively unexplored. Given the low cost and easy availability of N-propargylamines, the synthesis of functionalized morphol...

Silver catalyzed cascade synthesis of alkaloid ring systems: concise total synthesis of fascaplysin, homofascaplysin C and analogues.

A silver catalyzed and microwave assisted one-pot cascade synthesis provides efficient access to diverse alkaloid-inspired scaffold classes, and a concise and efficient total synthesis of homofascaplysin C and fascaplysin.

Concise Total Synthesis of (+)-Gliocladins B and C.

The first total synthesis of (+)-gliocladin B is described. Our concise and enantioselective synthesis takes advantage of a new regioselective Friedel-Crafts-based strategy to provide an efficient multigram-scale access to the C3-(3'-indolyl)hexahydropyrroloindole substructure, a molecular foundation present in a significant subset of epipolythiodiketopiperazine natural alkaloids. Our first-gen...